Clone:
REA1054
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
TCR Vα24-JαQ, TCR Va24-JαQ

Specifications for iNKT Antibody, anti-human, REAfinity™

Overview

Clone REA1054 recognizes human iNKT cells. Natural killer T (NKT) cells represent a distinct lymphocyte population that co-expresses T cell and NK cell surface markers. A subset of human NKT cells, referred to as iNKT cells, expresses an invariant TCR α-chain with certain TCR β-chains (Vα24-Jα18 combined with Vβ11). The iNKT cells are implicated in immunoregulatory processes such as tolerance, host defense, and tumor surveillance.
Additional information: Clone REA1054 displays negligible binding to Fc receptors.

Alternative names

TCR Vα24-JαQ, TCR Va24-JαQ

Detailed product information

Technical specifications

CloneREA1054
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigeniNKT
Alternative names of antigenTCR Vα24-JαQ, TCR Va24-JαQ
Molecular mass of antigen [kDa]93
Distribution of antigenNKT cells
Entrez Gene ID28659, 28747, 28582, 28581, 933
RRIDAB_2733675, AB_2733868, AB_2733869, AB_2733427, AB_2733428, AB_2733000, AB_2733001, AB_2733266, AB_2733267, AB_2733552, AB_2733553, AB_2733674

Resources for iNKT Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for iNKT Antibody, anti-human, REAfinity™

Publications

  1. Montoya, J. C. et al. (2007) Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11. Immunology 122: 1-14
  2. Exley, M. et al. (2008) Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR α-chain CDR3 loop. Eur. J. Immunol. 38: 1756-1766

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