Clone:
REA371
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Il30, p28, IL-27A

Specifications for IL-27 p28 Antibody, anti-mouse, REAfinity™

Overview

Clone REA371 recognizes the mouse IL-27 p28 antigen, a secreted molecule which binds Epstein-Barr virus-induced gene 3 (EBI3) to form the heterodimeric cytokine IL-27. IL-27 is expressed by antigen-presenting cells, including macrophages and dendritic cells, in the early phase after antigen-mediated activation. It can skew T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and has diverse effects on innate immune cells. In vivo, its most important role appears to be that of immune regulation, as mice with defects in IL-27 or its receptor display enhanced immune responses in a range of infectious and noninfectious situations. These activities of IL-27 are dependent on simultaneous T cell receptor activation and occur in synergy with IL-12. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL-27 p28 is only poorly secreted without coexpression of EBI3.
Additional information: Clone REA371 displays negligible binding to Fc receptors.

Alternative names

Il30, p28, IL-27A

Detailed product information

Technical specifications

CloneREA371
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-27 p28
Alternative names of antigenIl30, p28, IL-27A
Molecular mass of antigen [kDa]24
Distribution of antigendendritic cells, macrophages
Entrez Gene ID246779
RRIDAB_2652437, AB_2652438, AB_2652439, AB_2652440, AB_2652441, AB_2652436

Resources for IL-27 p28 Antibody, anti-mouse, REAfinity™

Certificates

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References for IL-27 p28 Antibody, anti-mouse, REAfinity™

Publications

  1. Pflanz, S. et al. (2002)
    IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4
    +
    T cells.
    Immunity 16(6): 779-790
  2. Lucas, S. et al. (2003)
    IL-27 regulates IL-12 responsiveness of naive CD4
    +
    T cells through Stat1-dependent and -independent mechanisms.
    Proc. Natl. Acad. Sci. U.S.A. 100(25): 15047-15052
  3. Batten, M. et al. (2007) The biology and therapeutic potential of interleukin 27. J. Mol. Med. 85(7): 661-672

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