Clone:
REA136
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40

Specifications for IL-12 (p40/p70) Antibody, anti-mouse, REAfinity™

Overview

Clone REA136 recognizes the 40 kDa p40 subunit of mouse IL-12, either in free form, as a homodimer or when it is expressed a part of heterodimeric IL-12 and IL-23 cytokines, where it associates with p35 and p19 subunit respectively. p40 shows homology to the extracellular domain of the members of haematopoietic cytokine-receptor family. Expression of p40 is restricted to cells producing IL-12.
Additional Information: Clone REA136 displays negligible binding to Fc receptors.

Alternative names

IL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40

Detailed product information

Technical specifications

CloneREA136
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-12 (p40/p70)
Alternative names of antigenIL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40
Molecular mass of antigen [kDa]40
Distribution of antigendendritic cells, macrophages
RRIDAB_2652332, AB_2652331

Resources for IL-12 (p40/p70) Antibody, anti-mouse, REAfinity™

Certificates

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References for IL-12 (p40/p70) Antibody, anti-mouse, REAfinity™

Publications

  1. Oppmann, B. et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13(5): 715-725
  2. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146

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