Human Noggin is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human Noggin

Overview

Human Noggin is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human Noggin can be used for a variety of applications, including:
  • ES/ iPS differentiation into neural stem cells and retinal cells.
  • Differentiation of human ES and iPS cell-derived endodermal lineages.
  • Induction of adipogenic differentiation of MSCs.

Detailed product information

Background information

Noggin is a disulfide-linked homodimer that acts by binding members of the TGF-β family, and consequently blocks their ability to signal through their receptors. Noggin plays a crucial role in regulating developmental processes by inhibiting the signaling pathway of bone morphogenetic protein 4 (BMP-4), as well as other BMPs. During embryogenesis Noggin is produced by the dorsal mesoderm and is important for the correct bone morphology and neural tissue formation. Mutations in the Noggin-coding gene (NOG) are associated with several bone diseases. The sequence of Noggin protein shows high homology across several species.

Biological activity

  • Inhibition of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells
  • research grade: ≥ 3.3×
    10
    5
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human Noggin

Documents and Protocols

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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