Human IL-31 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human IL-31

Overview

Human IL-31 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human IL-31 can be used for a variety of applications, including:
  • Skin disease research.
  • Dendritic cell research.

Detailed product information

Background information

Human IL-31 plays a role in inflammation of the skin. It is preferentially produced by type 2 helper T cells. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. Signaling also involves the JAK/STAT pathway, the PI3 kinase/AKT cascade, and the MAP kinase pathway.

Biological activity

  • STAT3 activation in human U87 cells.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human IL-31

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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