Clone:
REA406
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
HLA-DMA, HLA-DMB, DMA, HLADM, RING6, D6S221E, RING7

Specifications for HLA-DM Antibody, anti-human, REAfinity™

Overview

Clone REA406 recognizes the human HLA-DM antigen, a non-classical MHC class II molecule (MHC II) chaperone that works in lysosomes and endosomes. MHC II molecules are transmembrane glycoproteins which function by binding processed antigenic peptides and presenting them to CD4
+
T lymphocytes to initiate or maintain a specific immune response. Constitutive MHC II expression is restricted to professional antigen presenting cells including dendritic cells (DCs), B cells, and macrophages and to the epithelial cells of the thymus. Functional class II expression is highly dependent on the expression of two main chaperones, the invariant chain (Ii) and DM. Newly synthesized class II α- and β-chains form a nonameric complex with three Ii molecules in the endoplasmic reticulum where Ii blocks the peptide-binding groove and guides class II dimers to the endocytic pathway where Ii is proteolytically cleaved leaving the CLIP fragment bound to class II. HLA-DM, an endocytic chaperone, protects empty class II dimers until they bind a peptide capable to confer enough stability to the complex.
Additional information: Clone REA406 displays negligible binding to Fc receptors.

Alternative names

HLA-DMA, HLA-DMB, DMA, HLADM, RING6, D6S221E, RING7

Detailed product information

Technical specifications

CloneREA406
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-DM
Alternative names of antigenHLA-DMA, HLA-DMB, DMA, HLADM, RING6, D6S221E, RING7
Molecular mass of antigen [kDa]53(dimer)
Distribution of antigendendritic cells, B cells, macrophages, epithelial cells
Entrez Gene ID3108, 3109
RRIDAB_2876967, AB_2801985, AB_2801964, AB_2819608, AB_2819593, AB_2876966

Resources for HLA-DM Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for HLA-DM Antibody, anti-human, REAfinity™

Publications

  1. Oldford, S. A. et al. (2006) Tumor cell expression of HLA-DM associates with a Tʜ1 profile and predicts improved survival in breast carcinoma patients. Int. Immunol. 18(11): 1591-1602
  2. van Lith, M. et al. (2010) HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J. Biol. Chem. 285(52): 40800-40808
  3. Pos, W. et al. (2013) Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol. 34(10): 495-501

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