Clone:
REA672
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC

Specifications for HLA-BC Antibody, anti-human, REAfinity™

Overview

Clone REA672 recognizes the class I human leukocyte antigens (HLA) B and C. Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA672 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA672
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-BC
Molecular mass of antigen [kDa]38
Distribution of antigenT cells, NK cells
Entrez Gene ID3106, 3107
RRIDAB_2784367, AB_2819605, AB_2819590, AB_2811641, AB_2811636, AB_2652125, AB_2652126, AB_2652127, AB_2652128, AB_2652129, AB_2652130, AB_2652131, AB_2652132, AB_2652133, AB_2652134, AB_2652135, AB_2652136, AB_2784368

Resources for HLA-BC Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for HLA-BC Antibody, anti-human, REAfinity™

Publications

  1. Parham, P. et al. (1996) Population biology of antigen presentation by MHC class I molecules. Science 272(5258): 67-74
  2. Srivastava, R. et al. (1985) Molecular organization of the class I genes of human major histocompatibility complex. Immunol. Rev. 84: 93-121

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