Analysis of antigen-specific T cells is essential for the understanding of fundamental immunological processes. In immuno-oncology, they facilitate discovery of neo-antigens, but are also viewed as important immunotherapy effectors. Their ability to recognize and kill cancer cells make them an ideal target for immuno-oncology research.
However, working with antigen-specific T cells poses several challenges to researchers. Especially their low frequencies as rare cell population often hampers a reliable analysis. Specificity, inflammatory environment, subtype, as well as detection limit and background are determining factors and thus require optimized procedures in order to facilitate a successful experiment.
Miltenyi Biotec offers a complete research workflow tailored to enable analysis of these rare cell populations.
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