Clone:
HMD4-1
Type of antibody:
Primary antibodies
Isotype:
hamster IgG
Applications:
FC
Alternative names:
Delta4

Specifications for DLL4 Antibody, anti-mouse

Overview

DLL4 is one of the six identified Notch ligands in vertebrates. Being a canonical Notch ligand, extracellular domain of DLL4 contains N-terminal domain, Delta/Serrate/LAG-2 (DSL) domain and tandemly arranged multiple EGF like repeats. Binding of canonical ligands such as DLL4 induces cleavage and release of Notch intracellular domain (NICD), followed by its translocation in the nucleus where it interacts with transcription factors involved in induction of expression of Notch target genes. A ligand for Notch1, DLL4 is the first Notch ligand to be expressed during mouse development. DLL4 plays an important role in developmental angiogenesis. In mice, lack of a single DLL4 allele leads to early embryonic lethality characterized by severe defects in arterial differentiation and vascular remodeling.

Alternative names

Delta4

Detailed product information

Technical specifications

CloneHMD4-1
Clonalitymonoclonal
Isotypehamster IgG
Hosthamster
Type of antibodyPrimary antibodies
Speciesmouse
AntigenDLL4
Alternative names of antigenDelta4
Molecular mass of antigen [kDa]72
Distribution of antigenendothelial cells, heart
Entrez Gene ID54485
RRIDAB_2651571, AB_2651572, AB_2651573, AB_2651574, AB_2651575, AB_2651570

Resources for DLL4 Antibody, anti-mouse

Certificates

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References for DLL4 Antibody, anti-mouse

Publications

  1. Duarte, A. et al. (2004) Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 18: 2474 -2478
  2. Krebs, L. T. et al. (2004) Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev. 18: 2469 -2473
  3. D'Souza, B. et al. (2010) Canonical and non-canonical Notch ligands. Curr Top Dev Biol. 92: 73-129

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