Clone:
REA515
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CLEC7A, BGR, CANDF4, CD369, CLECSF12, DECTIN1

Specifications for Dectin-1 Antibody, anti-human, REAfinity™

Overview

Clone REA515 recognizes human DC-associated C-type lectin 1 (dectin-1), an approximately 33 kDa single-pass type II membrane protein, which is also known as C-type lectin domain family 7 member A (CLEC7A) or beta-glucan receptor (BGR). It promotes the phagocytosis of intact yeasts and glucan particles such as β-1,3-linked and β-1,6-glucans, thus playing an important role in anti-fungal immunity. In humans, eight isoforms of dectin-1 have been described. Only the two most common isoforms, dectin-1A and dectin-1B mediate the recognition of yeast particles in a beta-glucan-dependent manner. Monocytes express both dectin-1A and dectin-1B, while dectin-1A expression decreases during maturation to macrophages. Immature dendritic cells express high levels of both isoforms, but expression is lost when these cells are matured with LPS. Expression is also found on subpopulations of B cells, endothelial cells, eosinophils, fibroblasts, keratinocytes, Kupffer cells, Langerhans cells, mast cells, microglial cells, neutrophils, and T cells. In co-operation with TLR2 and TLR4, dectin-1 leads to cytokine production in human macrophages and monocytes.
Additional information: Clone REA515 displays negligible binding to Fc receptors.

Alternative names

CLEC7A, BGR, CANDF4, CD369, CLECSF12, DECTIN1

Detailed product information

Technical specifications

CloneREA515
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenDectin-1
Alternative names of antigenCLEC7A, BGR, CANDF4, CD369, CLECSF12, DECTIN1
Molecular mass of antigen [kDa]28
Distribution of antigendendritic cells, monocytes, macrophages, B cells, lymphocytes, granulocytes, endothelial cells, keratinocytes, Langerhans cells, mast cells, eosinophils, neutrophils
Entrez Gene ID64581
RRIDAB_2801821, AB_2651549, AB_2651550, AB_2651553, AB_2651554, AB_2801825

Resources for Dectin-1 Antibody, anti-human, REAfinity™

Certificates

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References for Dectin-1 Antibody, anti-human, REAfinity™

Publications

  1. Brown, G. D. et al. (2002) Dectin-1 is a major β-glucan receptor on macrophages. J. Exp. Med. 196(3): 407-412
  2. Iliev, I. D. et al. (2012) Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 338(6086): 1314-1317
  3. Yokota, K. et al. (2001) Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1. Gene 272(1-2): 51-60

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