Clone:
REAL648
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF

Specifications for Cytokeratin Antibody, anti-human, REAdye_lease™

Overview

Clone REAL648 is an antibody fragment derived from the full Cytokeratin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL648 recognizes Pan-Cytokeratin. Cytokeratins are polypeptides with keratin-containing intermediate filaments, which ensure form stability and cohesiveness. Keratins play a critical role in mechanical stability and integrity of epithelial cells and tissues, have regulatory functions and are involved in intracellular signaling pathways.
Anti-Cytokeratin detects cytokeratins which are expressed in normal and abnormal human tissues in epithelial cells and carcinomas. Anti-Cytokeratin is used to differentiate between epithelial carcinoma and non-epithelial malignancies.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Detailed product information

Technical specifications

CloneREAL648
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCytokeratin
Distribution of antigenepithelial cells, tumor cells, ubiquitous
RRIDAB_2857577, AB_2857575

Resources for Cytokeratin Antibody, anti-human, REAdye_lease™

Certificates

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References for Cytokeratin Antibody, anti-human, REAdye_lease™

Publications

  1. Makin, C. A. et al. (1984) Monoclonal antibody to cytokeratin for use in routine histopathology. J. Clin. Pathol. 37: 975-983
  2. Eichner, R. et al. (1984) Classification of epidermal keratins according to their immunoreactivity, isoelectric point, and mode of expression. J. Cell Biol. 98(4): 1388-1396
  3. Balasubramanian, P. et al. (2012) Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck. PLoS One 7(7)
  4. Xin, H. et al. (2014) Establishment and characterization of 7 novel hepatocellular carcinoma cell lines from patient-derived tumor xenografts. PLoS One 9(1): e85308
  5. Gown, A. M. et al. (1985) Monoclonal antibodies to human intermediate filament proteins. III. Analysis of tumors. Am. J. Clin. Pathol. 84(4): 413-424
  6. Battifora, H. (1988) Clinical applications of the immunohistochemistry of filamentous proteins. Am. J. Surg. Pathol. 12: 24-42

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