Clone:
REA1145
Type of antibody:
Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
KRT14, CK-14, Keratin-14, K14, Cytokeratin-14

Specifications for Cytokeratin 14 Antibody, anti-human, REAfinity™

Overview

Clone REA1145 recognizes cytokeratin 14. Cytokeratins, which are found in almost all epithelial cells, are polypeptides with keratin-containing intermediate filaments, which ensure form stability and cohesiveness. Keratins play a critical role in mechanical stability and integrity of epithelial cells and tissues, have regulatory functions and are involved in intracellular signaling pathways. Cytokeratin 14 is a member of the type I keratin family and is mainly found as a heterodimer with type II keratin 5 and forms the cytoskeleton of epithelial cells. It is located in in the basal layer and in the stratum spinosum, stratum granulosum and also expressed in the outer root sheath of anagen follicles and keratinocytes surrounding the club hair during telogen.
Additional information: Clone REA1145 displays negligible binding to Fc receptors.

Alternative names

KRT14, CK-14, Keratin-14, K14, Cytokeratin-14

Detailed product information

Technical specifications

CloneREA1145
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyRecombinant antibodies
Specieshuman, mouse, rat
Cross-reactivitymouse, rat
AntigenCytokeratin 14
Alternative names of antigenKRT14, CK-14, Keratin-14, K14, Cytokeratin-14
RRIDAB_2857493, AB_2857494, AB_2857492

Resources for Cytokeratin 14 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Cytokeratin 14 Antibody, anti-human, REAfinity™

Publications

  1. Hanukoglu, I. et al. (1982) The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins. Cell 31(1): 243-252
  2. Bowden, P. E. et al. (1998) Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. J. Invest. Dermatol. 110(2): 158-164

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