Clone:
2A9-1
Type of antibody:
Primary antibodies
Isotype:
rat IgG2bκ
Applications:
FC
Alternative names:
CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28

Specifications for CX3CR1 Antibody, anti-human

Overview

CX3CR1 is a transmembrane chemokine receptor with a molecular mass of 40 kDa. It binds the chemokine CX3CL1, also known as fractalkine or neurotactin. Binding of CX3CR1 to the membrane‑bound form of fractalkine promotes cell-cell adhesion, wheras the soluble form induces cell migration of CX3CR1-bearing cells such as monocytes, NK cells, T cells, dendritic cells (DCs), and macrophages including microglia.¹ CX3CR1 plays also an important role in the formation of transepithelial dendrites by intestinal DCs.² Failure in the fractalkine/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis.

Alternative names

CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28

Detailed product information

Technical specifications

Clone2A9-1
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Specieshuman
AntigenCX3CR1
Alternative names of antigenCCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
Molecular mass of antigen [kDa]40
Entrez Gene ID1524
RRIDAB_10828443, AB_2651468, AB_10828236, AB_2651469, AB_2651470, AB_10829616, AB_2651467

Resources for CX3CR1 Antibody, anti-human

Certificates

Please follow this
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References for CX3CR1 Antibody, anti-human

Publications

  1. Niess, J. H. et al. (2005)
    CX
    3
    CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
    Science 307: 254-258
  2. Imai, T. et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530

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