Clone:
REA281
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, FKN, NTT, SCYD1

Specifications for CX3CL1 Antibody, anti-human, REAfinity™

Overview

Clone REA281 recognizes the human C-X3-C motif chemokine 1 (CX3CL1) antigen, a single-pass type I membrane protein, which is also known as fractalkine or neurotactin. CX3CL1 is expressed in a number of cell types including neurons, intestinal epithelium, and activated vascular endothelium and is structurally distinct from other chemokines. The membrane-anchored form of CX3CL1 induces tight, shear-resistant endothelial adhesion of leukocytes in a manner that is independent of integrin and Gi protein activation. Soluble forms of CX3CL1 generated by proteolytic cleavage with the disintegrin and metalloproteinases CD156c (ADAM10) and CD156b (ADAM17) were shown to promote conventional chemotaxis of T cells and monocytes, but not of neutrophils. The sole receptor for CX3CL1 is CX3CR1, which is widely expressed by leukocytes, including CD14
+
cells of the monocyte-macrophage DC lineage and subsets of tissue-resident DCs and epidermal Langerhans cells. In addition to supporting leukocyte extravasation from the blood, the CX3CL1–CX3CR1 axis has been implicated in pathogenesis of inflammatory diseases such as atherosclerosis, rheumatoid arthritis, and renal fibrosis. CX3CL1 was also shown to promote extension of transepithelial dendrites by monocytes and/or DCs within intestinal lamina propria, for the purpose of antigen sensing in the intestinal lumen.
Additional information: Clone REA281 displays negligible binding to Fc receptors.

Alternative names

CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, FKN, NTT, SCYD1

Detailed product information

Technical specifications

CloneREA281
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCX3CL1
Alternative names of antigenCCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, FKN, NTT, SCYD1
Molecular mass of antigen [kDa]40(refers to membrane-bound form)
Distribution of antigenendothelial cells, epithelial cells, neurons
Entrez Gene ID6376
RRIDAB_2651464, AB_2651465, AB_2651466, AB_2651463

Resources for CX3CL1 Antibody, anti-human, REAfinity™

Certificates

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References for CX3CL1 Antibody, anti-human, REAfinity™

Publications

  1. Bazan, J. F. et al. (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385(6617): 640-644
  2. Papadopoulos, E. J. et al. (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur. J. Immunol. 29(8): 2551-2559
  3. Johnson, L. A. et al. (2013) The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics. J. Cell. Sci. 126(22): 5259-5270

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