Clone:
REA876
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CEA, CEACAM5

Specifications for CD66e Antibody, anti-human, REAfinity™

Overview

Clone REA876 recognizes the human CD66e antigen, a member of the immunoglobin superfamily which is also known as carcinoembryonic antigen (CEA) or CEA-related cell adhesion molecules 5 (CEACAM5). CD66e is GPI-linked glycosylated protein found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. CD66e and other CEACAMs are host receptors for the Dr family of adhesins of
Escherichia coli
. CD66e is an intercellular adhesion molecule and is able to inhibit cellular differentiation. The overexpression of CD66e is used as an indicator for tumor invasiveness.
Additional information: Clone REA876 displays negligible binding to Fc receptors.

Alternative names

CEA, CEACAM5

Detailed product information

Technical specifications

CloneREA876
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD66e
Alternative names of antigenCEA, CEACAM5
Molecular mass of antigen [kDa]71
Distribution of antigenepithelial cells, colon
Entrez Gene ID1048
RRIDAB_2726488, AB_2726559, AB_2726489, AB_2726560, AB_2726490, AB_2726557, AB_2726487, AB_2726558

Resources for CD66e Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD66e Antibody, anti-human, REAfinity™

Publications

  1. Taheri, M. et al. (2000) Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion. J. Biol. Chem. 275(35): 26935-26943
  2. Korotkova, N. et al. (2008)
    Binding of Dr adhesins of
    Escherichia coli
    to carcinoembryonic antigen triggers receptor dissociation.
    Mol. Microbiol. 67(2): 420-434

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