Clone:
REA981
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Integrin alpha-2, Itga2, Collagen receptor, intergrin α2 chain, VLA-2 α chain

Extended validation for CD49b Antibody, anti-mouse/rat, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA981
DX5++
HMα2+
REA541++
Ha1/29++
Cells were incubated with an excess of purified unconjugated CD49b (REA981) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD49b Antibody, anti-mouse/rat, REAfinity™

Overview

Clone REA981 recognizes the mouse and rat CD49b antigen, a transmembrane glycoprotein also known as integrin alpha-2 (Itga2). CD49 is found on activated lymphocytes, epithelial cells, and platelets. In association with CD29 (integrin β-1), a VLA-2 complex is formed, which functions as a receptor for collagen and collagen C-propeptides, laminin, and E-cadherin.
Additional information: Clone REA981 displays negligible binding to Fc receptors.

Alternative names

Integrin alpha-2, Itga2, Collagen receptor, intergrin α2 chain, VLA-2 α chain

Detailed product information

Technical specifications

CloneREA981
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse, rat
AntigenCD49b
Alternative names of antigenIntegrin alpha-2, Itga2, Collagen receptor, intergrin α2 chain, VLA-2 α chain
Molecular mass of antigen [kDa]126
Distribution of antigenlymphocytes, epithelial cells, platelets
Entrez Gene ID16398, 170921
RRIDAB_2727495, AB_2727536, AB_2727496, AB_2727537, AB_2727497, AB_2727541, AB_2727501, AB_2727538, AB_2727498, AB_2727539, AB_2727499, AB_2727540, AB_2727500, AB_2727534, AB_2727494, AB_2727535

Resources for CD49b Antibody, anti-mouse/rat, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD49b Antibody, anti-mouse/rat, REAfinity™

Publications

  1. Hemler, M. E. et al. (1990) LA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8: 365-400
  2. Wu, J. E. et al. (1994) Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Dev. Dyn. 199(4): 292-314

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