Clone:
REAL659
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Bp50, CD40L receptor, CDW40

Specifications for CD40 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL659 is an antibody fragment derived from the full CD40 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL659 recognizes the human CD40 antigen, a transmembrane receptor of the tumor necrosis factor gene superfamily. CD40 is a co-stimulatory protein constitutively expressed by antigen presenting cells, including dendritic cells, B cells, and macrophages and on endothelial, smooth muscle cells, and fibroblasts. The binding of CD40 to CD154 (CD40L) on T helper cells activates antigen presenting cells and enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules. CD40 has been shown to interact with members of the TRAF family.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Bp50, CD40L receptor, CDW40

Detailed product information

Technical specifications

CloneREAL659
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD40
Alternative names of antigenBp50, CD40L receptor, CDW40
Distribution of antigenantigen-presenting cells, B cells, endothelial cells, macrophages, dendritic cells, fibroblasts, other, smooth muscle, spleen
RRIDAB_2877044

Resources for CD40 Antibody, anti-human, REAdye_lease™

Certificates

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References for CD40 Antibody, anti-human, REAdye_lease™

Publications

  1. Stamenkovic, I. et al. (1989) A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8(5): 1403-1410
  2. Sato, T. et al. (1995) A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358(2): 113-118
  3. Chatzigeorgiou, A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors 35(6): 474-483

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