Clone:
REAL487
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
gp105-120, Mucosialin, My10

Specifications for CD34 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL487 is an antibody fragment derived from the full CD34 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL487 recognizes the human CD34 antigen, a single chain transmembrane glycoprotein, expressed on human hematopoietic stem and progenitor cells, endothelial progenitor cells, vascular endothelial cells, embryonic fibroblasts, and some cells in fetal and adult nervous tissue. The antigen is absent on fully differentiated hematopoietic cells such as normal peripheral blood lymphocytes, monocytes, granulocytes, erythrocytes, and platelets. CD34 antibodies can be used for studies of hematopoiesis and nonhematopoiectic stem cells, phenotyping of endothelial cells, and endothelial progenitor cells (EPCs), hematopoietic stem cells, and studies on phenotyping of hematologic malignancies, e.g. the identification of blasts in leukemia. Additionally it is a marker for solitary fibrous tumors and gastrointestinal stromal tumors.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

gp105-120, Mucosialin, My10

Detailed product information

Technical specifications

CloneREAL487
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD34
Alternative names of antigengp105-120, Mucosialin, My10
Distribution of antigenstem cells, endothelial cells, fibroblasts, tumor cells, neurons, fetal neuronal progenitor cells, hematopoietic stem and progenitor cells, leukemia cells, neural stem cells, other, tonsil, bone marrow
RRIDAB_2877043, AB_2877039

Resources for CD34 Antibody, anti-human, REAdye_lease™

Certificates

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References for CD34 Antibody, anti-human, REAdye_lease™

Publications

  1. Stull, R. A. et al. (2000) Simultaneous flow cytometric analyses of enhanced green and yellow fluorescent Cytometry 40: 126-134
  2. Metsuyanim, S. et al. (2009) Expression of stem cell markers in the human fetal kidney. PLoS One 4(68): e6709
  3. De Paepe, M. E. et al. (2011) Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells. Am. J. Pathol. 178(3): 1329-1339
  4. Bility, M. T. et al. (2012) Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis. Nat. Protoc. 7(9): 1608-1617
  5. Vets, S. et al. (2012) Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. Mol. Ther. 20(5): 908-917
  6. Liu, H. et al. (2013) Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells. Cell Death Dis 4: e857
  7. Lian, W. et al. (2014)
    Varying levels of 6-keto-prostaglandin F1α and thromboxane B2 in serum and endothelialization and hyperplasia in small-diameter grafts seeded with CD34
    +
    bone marrow cells in canines.
    Exp Ther Med. 7(5): 1123-1129

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