Clone:
REA605
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
JAM-1, JAM-A, PAM-1, F11 R

Specifications for CD321 (JAM1) Antibody, anti-human, REAfinity™

Overview

Clone REA605 recognizes the human CD321 antigen, a cell-surface adhesion molecule, also known as JAM1 or JAMA. CD321 is a type I transmembrane glycoprotein belonging to the immunoglobin superfamily. It has two extracellular Ig-like domains, a transmembrane region and a short cytosolic tail.
CD321 is expressed on a variety of cell types: erythrocytes, leukocytes, platelets, as well as endothelial and epithelial cells. CD321 has different functions. It is a regulator of tight junction assembly in epithelia and acts as a receptor for reovirus. Furthermore CD321 binds integrin LFA1 and is involved in leukocyte transmigration. In addition, CD321 is a platelet receptor.
Additional information: Clone REA605 displays negligible binding to Fc receptors.

Alternative names

JAM-1, JAM-A, PAM-1, F11 R

Detailed product information

Technical specifications

CloneREA605
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD321 (JAM1)
Alternative names of antigenJAM-1, JAM-A, PAM-1, F11 R
Molecular mass of antigen [kDa]30
Distribution of antigenendothelial cells, epithelial cells, platelets, red blood cells, leukocytes
Entrez Gene ID50848
RRIDAB_2657454, AB_2657455, AB_2657456, AB_2657457, AB_2657458, AB_2657459, AB_2657460, AB_2657461, AB_2657462, AB_2657463, AB_2657464, AB_2657465, AB_2657466, AB_2657467

Resources for CD321 (JAM1) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD321 (JAM1) Antibody, anti-human, REAfinity™

Publications

  1. Fraemohs, L. et al. (2004) The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain. J. Immunol. 173(10): 6259-6264
  2. Ozaki, H. et al. (1999) Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J. Immunol. 163(2): 553-557
  3. Sobocka, M. B. et al. (2000) Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood 95(8): 2600-2609

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