Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
JAM-1, JAM-A, PAM-1, F11 R

Specifications for CD321 (JAM1) Antibody, anti-human, REAfinity™


Clone REA605 recognizes the human CD321 antigen, a cell-surface adhesion molecule, also known as JAM1 or JAMA. CD321 is a type I transmembrane glycoprotein belonging to the immunoglobin superfamily. It has two extracellular Ig-like domains, a transmembrane region and a short cytosolic tail.
CD321 is expressed on a variety of cell types: erythrocytes, leukocytes, platelets, as well as endothelial and epithelial cells. CD321 has different functions. It is a regulator of tight junction assembly in epithelia and acts as a receptor for reovirus. Furthermore CD321 binds integrin LFA1 and is involved in leukocyte transmigration. In addition, CD321 is a platelet receptor.
Additional information: Clone REA605 displays negligible binding to Fc receptors.

Alternative names

JAM-1, JAM-A, PAM-1, F11 R

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenCD321 (JAM1)
Alternative names of antigenJAM-1, JAM-A, PAM-1, F11 R
Molecular mass of antigen [kDa]30
Distribution of antigenendothelial cells, epithelial cells, platelets, red blood cells, leukocytes
Entrez Gene ID50848
RRIDAB_2657454, AB_2657455, AB_2657456, AB_2657457, AB_2657458, AB_2657459, AB_2657460, AB_2657461, AB_2657462, AB_2657463, AB_2657464, AB_2657465, AB_2657466, AB_2657467

Resources for CD321 (JAM1) Antibody, anti-human, REAfinity™


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References for CD321 (JAM1) Antibody, anti-human, REAfinity™


  1. Fraemohs, L. et al. (2004) The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain. J. Immunol. 173(10): 6259-6264
  2. Ozaki, H. et al. (1999) Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J. Immunol. 163(2): 553-557
  3. Sobocka, M. B. et al. (2000) Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood 95(8): 2600-2609

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