Clone:
REA380
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
NRP1, NP-1, NPN-1, Nrp

Specifications for CD304 (BDCA-4) Antibody, anti-mouse, REAfinity™

Overview

Clone REA380 recognizes the mouse CD304 antigen, a single-pass type I membrane protein also known as neuropilin-1 or blood dendritic cell antigen-4 (BDCA-4). There are differences in the CD304 expression between mice and humans. In mice, CD304 is selectively expressed on natural T regulatory cells and greatly enhances immunosuppressive function. It is also expressed on a subset of invariant natural killer T cells, endothelial cells, and neurons. In humans, CD304 is expressed on plasmacytoid dendritic cells where it aids in priming immune responses and on a subset of T regulatory cells isolated from secondary lymph nodes. CD304 acts as a coreceptor for a number of extracellular ligands including class III/IV semaphorins, certain isoforms of vascular endothelial growth factor and transforming growth factor beta. It is involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits, and in organogenesis outside the nervous system.
Additional information: Clone REA380 displays negligible binding to Fc receptors.

Alternative names

NRP1, NP-1, NPN-1, Nrp

Detailed product information

Technical specifications

CloneREA380
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD304 (BDCA-4)
Alternative names of antigenNRP1, NP-1, NPN-1, Nrp
Molecular mass of antigen [kDa]101
Distribution of antigendendritic cells
Entrez Gene ID18186
RRIDAB_2876942, AB_2801788

Resources for CD304 (BDCA-4) Antibody, anti-mouse, REAfinity™

Certificates

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References for CD304 (BDCA-4) Antibody, anti-mouse, REAfinity™

Publications

  1. Delgoffe, G. M. et al. (2013) Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 501(7466): 252-256
  2. Yadav, M. et al. (2012)
    Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets
    in vivo
    .
    J. Exp. Med. 209(10): 1713-1722
  3. Kawakami, A. et al. (1996) Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous System. J. Neurobiol. 29(1): 1-17
  4. Smith, N. et al. (2017) Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun. 8: 14253

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