Clone:
REA587
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
L-SIGN, DC-SIGN-related protein, CLEC4M

Specifications for CD299 (L-SIGN) Antibody, anti-human, REAfinity™

Overview

Clone REA587 recognizes the human CD299 (L-SIGN) antigen, a type II integral membrane protein, also known as C-type lectin domain family 4 member M (CLEC4M) or liver/lymph node-specific ICAM-3-grabbing non-integrin. CD299 is expressed by sinusoidal endothelial cells in lymph nodes and is found in placental endothelium but not in macrophages. It is also expressed in type II alveolar cells and lung endothelial cells. CD299 has a high affinity for both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells.
Additional information: Clone REA587 displays negligible binding to Fc receptors.

Alternative names

L-SIGN, DC-SIGN-related protein, CLEC4M

Detailed product information

Technical specifications

CloneREA587
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD299 (L-SIGN)
Alternative names of antigenL-SIGN, DC-SIGN-related protein, CLEC4M
Molecular mass of antigen [kDa]45
Distribution of antigenendothelial cells, placenta
Entrez Gene ID10332
RRIDAB_2657047, AB_2657048, AB_2657049, AB_2657050, AB_2657051, AB_2657052, AB_2657053, AB_2657054, AB_2657055, AB_2657056, AB_2657057, AB_2657046

Resources for CD299 (L-SIGN) Antibody, anti-human, REAfinity™

Certificates

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References for CD299 (L-SIGN) Antibody, anti-human, REAfinity™

Publications

  1. Bashirova, A. A. et al. (2001) A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J. Exp. Med. 193(6): 671-678
  2. Jeffers, S. A. et al. (2004) CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc. Natl. Acad. Sci. U.S.A. 101(44): 15748-15753
  3. Pöhlmann, S. et al. (2001) DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc. Natl. Acad. Sci. U.S.A. 98(5): 2670-2675

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