Clone:
REA206
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CD28RNA

Specifications for CD28 Antibody, anti-rat, REAfinity™

Overview

Clone REA206 recognizes rat CD28, a 44 kDa glycoprotein also known as Tp44. CD28 is a homodimeric type I transmembrane protein of the Ig receptor superfamily, composed of disulfide-linked subunits. It is a costimulatory molecule which is expressed on most thymocytes, CD4
+
and CD8
+
T cells, and NK cells. Expression of CD28 is down-regulated at late stages of terminal effector T cell differentiation. Ligation of CD28 with CD80 (B7-1) and CD86 (B7-2) provides a costimulatory signal for T cell activation.
Additional information: Clone REA206 displays negligible binding to Fc receptors.

Alternative names

CD28RNA

Detailed product information

Technical specifications

CloneREA206
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD28
Alternative names of antigenCD28RNA
Molecular mass of antigen [kDa]23
Distribution of antigenT cells
Entrez Gene ID25660
RRIDAB_2656942, AB_2656943, AB_2656944, AB_2656945, AB_2656946, AB_2656947, AB_2656948, AB_2656949, AB_2656950, AB_2656941

Resources for CD28 Antibody, anti-rat, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD28 Antibody, anti-rat, REAfinity™

Publications

  1. Clark, G. J. et al. (1992) Identification of a cDNA encoding the rat CD28 homologue. Immunogenetics 35(1): 54-57
  2. Guo, L. et al. (2003) Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Transpl Immunol. 12(1): 41-48

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