Clone:
REA990
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50

Specifications for CD275 (B7-H2) Antibody, anti-mouse, REAfinity™

Overview

Clone REA990 recognises the mouse CD275 antigen, which is also known as B7-H2 or ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of co-stimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 co-stimulates T cells upon binding to inducible T cell co-stimulator (ICOS), which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell co-stimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells.
Additional information: Clone REA990 displays negligible binding to Fc receptors.

Alternative names

ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50

Detailed product information

Technical specifications

CloneREA990
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD275 (B7-H2)
Alternative names of antigenICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50
Molecular mass of antigen [kDa]31
Distribution of antigendendritic cells, macrophages, monocytes, B cells, antigen-presenting cells
Entrez Gene ID50723
RRIDAB_2727547, AB_2727507, AB_2727548, AB_2727551, AB_2727509, AB_2727549, AB_2727550, AB_2727508, AB_2727546, AB_2727506

Resources for CD275 (B7-H2) Antibody, anti-mouse, REAfinity™

Certificates

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References for CD275 (B7-H2) Antibody, anti-mouse, REAfinity™

Publications

  1. Watanabe, M. et al. (2008) Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J. Immunol. 180: 5222-5234
  2. Yao, S. et al. (2011) B7-H2 is a costimulatory ligand for CD28 in human. Immunity 34(5): 729-740

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