Clone:
REA1217
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
BAFF-R, BLyS receptor 3, TNFRSF13c, BAFFR, Bcmd, BR3

Specifications for CD268 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1217 recognizes the CD268 protein, also known as B cell activation factor receptor (BAFF-R), which is a type III transmembrane TNF receptor family member. CD268 is expressed at high levels on resting B cells, at lower levels on activated B cells, and on a small subset of activated/memory T cells. BAFF, also known as BLys, mediates costimulatory responses in peripheral B and T cells. BAFF is a key regulator for B cell differentiation as well as survival and activation of peripheral B cell populations. Accordingly, CD268 appears to be particularly involved in the regulation of normal B cell survival and maturation, but also in the pathophysiology of aggressive B cell malignancies and autoimmune diseases.
Additional information: Clone REA1217 displays negligible binding to Fc receptors.

Alternative names

BAFF-R, BLyS receptor 3, TNFRSF13c, BAFFR, Bcmd, BR3

Detailed product information

Technical specifications

CloneREA1217
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD268
Alternative names of antigenBAFF-R, BLyS receptor 3, TNFRSF13c, BAFFR, Bcmd, BR3
Molecular mass of antigen [kDa]19
Distribution of antigenB cells, T cells, B cell subsets, memory T cells
Entrez Gene ID72049
RRIDAB_2811524, AB_2811525, AB_2811526, AB_2811523

Resources for CD268 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
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References for CD268 Antibody, anti-mouse, REAfinity™

Publications

  1. Thompson, J. S. et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293(5537): 2108-2111
  2. Ng, L. G. et al. (2006) BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 36(7): 1837-1846

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