Clone:
ITEM-4
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2bκ
Applications:
FC
Alternative names:
TNFRSF12A, FN14, TWEAKR

Specifications for CD266 (FN14) Antibody, anti-human/mouse

Overview

Clone ITEM-4 recognizes CD266, also known as FN14, tumor necrosis factor receptor superfamily member 12A (TNFRSF12A), or tweak-receptor (TweakR). CD266 is a 14 kDa type I transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily and binds to TWEAK, a proinflammatory cytokine, as its only known ligand. The cytoplasmic tail of CD266 contains a TRAF binding motif and binds to TRAF1, TRAF2, TRAF3, and TRAF5. Both TWEAK dependent and independent CD266 signaling lead to activation of the NF-κB pathway. TWEAK independent signaling is shown when CD266 is ectopically overexpressed
in vitro
. Expression of CD266 is found on a wide variety of cells except for primary T and B cells. Elevated expression is often found in response to several growth factors, cytokines, hormones, TWEAK, after tissue injury and in solid tumors such as glioblastoma multiforme tumors. Varied functions of TWEAK signaling include promotion of wound healing and regeneration, to influence the transition from innate to adaptive immunity and regulation of cell death and tumor progression.

Alternative names

TNFRSF12A, FN14, TWEAKR

Detailed product information

Technical specifications

CloneITEM-4
Clonalitymonoclonal
Isotypemouse IgG2bκ
Isotype controlIsotype Control Antibody, mouse IgG2b
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, mouse
AntigenCD266 (FN14)
Alternative names of antigenTNFRSF12A, FN14, TWEAKR
Molecular mass of antigen [kDa]11
Distribution of antigenB cells, T cells
Entrez Gene ID51330
RRIDAB_2656763, AB_2656764, AB_2656765, AB_2656766, AB_2656767, AB_2656768, AB_2656769, AB_2656762

Resources for CD266 (FN14) Antibody, anti-human/mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD266 (FN14) Antibody, anti-human/mouse

Publications

  1. Nakayama, M. et al. (2003) Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J. Immunol. 170: 341-348
  2. Vince, J. E. et al. (2006) TWEAK shall inherit the earth. Cell Death Differ. 13(11): 1842-1844
  3. Winkles, J. A. (2008) The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting. Nat. Rev. Drug Discov. 7(5): 411-425

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