Clone:
REA273
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Ly-9, Lgp100, SLAMF3, T100, Lymphocyte antigen 9

Specifications for CD229 (Ly-9) Antibody, anti-mouse, REAfinity™

Overview

Clone REA273 recognizes both mouse CD229 antigen alleles, Ly9.1 and Ly9.2. CD229 is a glycoprotein of the SLAM family also known as Ly9 or SLAMF3 which is a homophilic cell surface receptor present on a variety of immune cell types including T cells, B cells, NK cells, and thymocytes. It has been shown to interact with the adaptor proteins, SLAM-associated protein and EAT-2. CD229 is highly expressed on innate-like lymphocytes such as iNKT cells and in contrast to SLAMF1 and SLAMF6, CD229 plays a negative rather than a positive role in the signaling pathways required for innate-like lymphocyte development in the thymus.
Additional Information: Clone REA273 displays negligible binding to Fc receptors.

Alternative names

Ly-9, Lgp100, SLAMF3, T100, Lymphocyte antigen 9

Detailed product information

Technical specifications

CloneREA273
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD229 (Ly-9)
Alternative names of antigenLy-9, Lgp100, SLAMF3, T100, Lymphocyte antigen 9
Molecular mass of antigen [kDa]68
Distribution of antigenB cells, T cells, NK cells
Entrez Gene ID17085
RRIDAB_2656442, AB_2656443, AB_2656444, AB_2656445, AB_2656446, AB_2656447, AB_2656448, AB_2656449, AB_2656452, AB_2656453

Resources for CD229 (Ly-9) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD229 (Ly-9) Antibody, anti-mouse, REAfinity™

Publications

  1. Romero, X. et al. (2005) CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. J. Immunol. 174(11): 7033-7042
  2. Sintes, J. et al. (2013)
    Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8
    +
    T and invariant NKT cells.
    J. Immunol. 190: 21-26
  3. Tovar, V. et al. (2000) Gene structure of the mouse leukocyte cell surface molecule Ly9. Immunogenetics 51(10): 788-793

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