Clone:
REA717
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Melanotransferrin, MFI2, MAP97, MTF1

Specifications for CD228 Antibody, anti-human, REAfinity™

Overview

Clone REA717 recognizes the human CD228 antigen, a cell-surface sialoglycoprotein also known as MFI2 or melanotransferrin. CD228 is mainly found in human melanomas, but also in liver, epithelium, and in certain fetal tissues. It plays a role in iron cellular uptake. CD228 is internalized before being recycled back to the cell membrane and is also able to bind zinc.
Additional information: Clone REA717 displays negligible binding to Fc receptors.

Alternative names

Melanotransferrin, MFI2, MAP97, MTF1

Detailed product information

Technical specifications

CloneREA717
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD228
Alternative names of antigenMelanotransferrin, MFI2, MAP97, MTF1
Molecular mass of antigen [kDa]76
Distribution of antigenepithelial cells, melanoma, liver, melanoma
Entrez Gene ID4241
RRIDAB_2656435, AB_2656436, AB_2656437, AB_2656438, AB_2656439, AB_2656440, AB_2656441, AB_2656434

Resources for CD228 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD228 Antibody, anti-human, REAfinity™

Publications

  1. Baker, E. N. et al. (1992) Human melanotransferrin (p97) has only one functional iron-binding site. FEBS Lett. 298(2-3): 215-218
  2. Kennard, M. L. et al. (1995) A novel iron uptake mechanism mediated by GPI-anchored human p97. EMBO J. 14(17): 4178-4186
  3. Suryo Rahmanto, Y. et al. (2007) The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis. Oncogene 26(42): 6113-6124

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