Clone:
REA239
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL10RA, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, IL-10Rα

Specifications for CD210 (IL-10R) Antibody, anti-human, REAfinity™

Overview

Clone REA239 recognizes the human CD210 antigen, a 90–110 kDa protein, which is also known as IL-10 receptor (IL-10R) alpha subunit. CD210 is expressed on various cell types like monocytes, B cells, large granular lymphocytes, and T cells. The IL-10R protein is structurally related to interferon receptors. Functional IL-10R complexes are tetramers consisting of two IL-10Rα polypeptide chains and two IL-10Rβ chains. Binding of IL-10 to the extracellular domain of IL-10Rα activates the IL-10 signal transduction pathway by inducing phosphorylation of STAT1a and STAT3 and by inducing activation of Jak1 and Tyk. IL-10R has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines.
Additional information: Clone REA239 displays negligible binding to Fc receptors.

Alternative names

IL10RA, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, IL-10Rα

Detailed product information

Technical specifications

CloneREA239
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD210 (IL-10R)
Alternative names of antigenIL10RA, CD210a, CDW210A, HIL-10R, IL-10R1, IL10R, IL-10Rα
Distribution of antigenB cells, T cells, monocytes
RRIDAB_2811374, AB_2656315, AB_2656316, AB_2811377

Resources for CD210 (IL-10R) Antibody, anti-human, REAfinity™

Certificates

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References for CD210 (IL-10R) Antibody, anti-human, REAfinity™

Publications

  1. Liu, Y. et al. (1994) Expression cloning and characterization of a human IL-10 receptor. J. Immunol. 152: 1821-1829
  2. Donnelly, R. P. et al. (1999) The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J. Interferon Cytokine Res. 19(6): 563-573
  3. Tan, J. C. et al. (1995) Characterization of recombinant extracellular domain of human interleukin-10 receptor. J. Biol. Chem. 270: 12906-12911
  4. Siegmund, D. et al. (2016) Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis. Cell Death Dis 7(9): e2375

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