Clone:
REA822
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Langerin

Specifications for CD207 (Langerin) Antibody, anti-mouse, REAfinity™

Overview

Clone REA822 recognizes the mouse CD207 antigen, also known as Langerin, which is a 48 kDa transmembrane type II C-type lectin containing a single carbohydrate recognition domain in its extracellular region. Langerin is specifically expressed on epidermal Langerhans cells and dermal CD103
+
dendritic cells. It displays Ca
2+
-dependent binding specificity for mannose, N-acetyl-glucosamine, and fucose and is involved in antigen recognition, uptake, and transport to the Birbeck granules, whose formation is dependent on Langerin expression. The CD207 epitope shows trypsin as well as collagenase sensitivity.
Additional information: Clone REA822 displays negligible binding to Fc receptors.

Alternative names

Langerin

Detailed product information

Technical specifications

CloneREA822
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD207 (Langerin)
Alternative names of antigenLangerin
Molecular mass of antigen [kDa]38
Distribution of antigenLangerhans cells, dendritic cells
Entrez Gene ID246278
RRIDAB_2725910, AB_2725923, AB_2725911, AB_2725924, AB_2725912, AB_2725928, AB_2725913, AB_2725925, AB_2725926, AB_2725927, AB_2725921, AB_2725909, AB_2725922

Resources for CD207 (Langerin) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD207 (Langerin) Antibody, anti-mouse, REAfinity™

Publications

  1. Valladeau, J. et al. (2002) Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J. Immunol. 168(2): 782-792
  2. Idoyaga, J. et al. (2008)
    Cutting edge: Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products
    in vivo
    .
    J. Immunol. 180(6): 3647-3650

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