Clone:
REA770
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CLEC4K, Langerin

Specifications for CD207 (Langerin) Antibody, anti-human, REAfinity™

Overview

Clone REA770 recognizes the CD207 antigen, a 40 kDa glycosylated type II transmembrane C-type lectin receptor, and the standard marker for human and murine Langerhans cells (LCs). LCs are a subset of dendritic cells (DCs) that reside in epithelia; the best studied example of these antigen-presenting cells are LCs of the epidermis. CD207 is directly involved in antigen capture as well as endocytosis and induces the formation of typical Birbeck granules in immature DCs.
Additional information: Clone REA770 displays negligible binding to Fc receptors.

Alternative names

CLEC4K, Langerin

Detailed product information

Technical specifications

CloneREA770
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD207 (Langerin)
Alternative names of antigenCLEC4K, Langerin
Molecular mass of antigen [kDa]37
Distribution of antigenLangerhans cells, dendritic cells
Entrez Gene ID50489
RRIDAB_2656209, AB_2656210, AB_2656211, AB_2656212, AB_2656213, AB_2656214, AB_2656215, AB_2656216, AB_2656217, AB_2656218, AB_2656219, AB_2656220, AB_2656221, AB_2656222, AB_2656223, AB_2656224, AB_2656225, AB_2656208

Resources for CD207 (Langerin) Antibody, anti-human, REAfinity™

Certificates

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References for CD207 (Langerin) Antibody, anti-human, REAfinity™

Publications

  1. Geissmann, F. et al. (1998) Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells J. Exp. Med. 187(6): 961-996
  2. Valladeau, J. et al. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12(1): 71-81
  3. Rozis, G. et al. (2008) Human Langerhans cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands Immunology 124(3): 329-338
  4. Romani, N. et al. (2010) Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol. Rev. 234(1): 120-141
  5. Stoitzner, P. et al. (2010) Isolation of skin dendritic cells from mouse and man. Methods Mol. Biol. 595: 235-248

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