Clone:
REA460
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
MSR1, SCARA1, SR-A, phSR1, phSR2, SR-AI

Specifications for CD204 Antibody, anti-human, REAfinity™

Overview

Clone REA460 recognizes the human CD204 antigen, a single-pass type II membrane protein which is also known as macrophage scavenger receptor type I (MSR1) or scavenger receptor class A (SR-A). CD204 is one of the major scavenger receptors expressed on human macrophages and dendritic cells. It plays roles in lipid metabolism, atherogenesis, and a number of metabolic processes. Recent evidence also points to important roles for CD204 in inflammation, innate immunity, host defense, sepsis, and ischemic injury. CD204 inhibits macrophage activation by scavenging ligands of toll-like receptor 4 and suppresses inflammatory cytokine production. Immunohistochemical studies in gliomas, pancreatic cancer, kidney cancer, esophageal cancer, and lung cancer have shown that CD204 expression in tumor tissues is closely restricted to tumor-associated macrophages and that high expression of CD204 is associated with a high malignant potential of tumor cells.
Additional information: Clone REA460 displays negligible binding to Fc receptors.

Alternative names

MSR1, SCARA1, SR-A, phSR1, phSR2, SR-AI

Detailed product information

Technical specifications

CloneREA460
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD204
Alternative names of antigenMSR1, SCARA1, SR-A, phSR1, phSR2, SR-AI
Molecular mass of antigen [kDa]50
Distribution of antigenmacrophages, dendritic cells
Entrez Gene ID4481
RRIDAB_2819383, AB_2857487, AB_2857485, AB_2656188, AB_2656189, AB_2819384

Resources for CD204 Antibody, anti-human, REAfinity™

Certificates

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References for CD204 Antibody, anti-human, REAfinity™

Publications

  1. Matsumoto, A. et al. (1990) Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc. Natl. Acad. Sci. U.S.A. 87(23): 9133-9137
  2. Yi, H. et al. (2011) Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity. Cancer Res. 71(21): 6611-6620
  3. Saito, Y. et al. (2014) Role of CD204-positive tumor-associated macrophages in adult T-cell leukemia/lymphoma. J. Clin. Hematop. 54(1): 59-65

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