Clone:
REA826
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ENPP3, B10, NPP3, PD-IBETA, PDNP3, E-NPP3, PD-1b

Specifications for CD203c Antibody, anti-human, REAfinity™

Overview

Clone REA826 recognizes the human CD203c antigen, a glycosylated type II transmembrane molecule that belongs to the family of ecto-nucleotide pyrophosphatase/ phosphodiesterase (E-NPP3) enzymes. Among hematopoietic cells, expression of CD203c is restricted to basophils, mast cells, and their precursors, and has been described as specific for this lineage. Protein and/or mRNA expression of CD203c has also been found in solid tissues such as uterus or prostate. Basophils and mast cells are key producers of mediators that drive the onset of inflammatory responses, e.g., in allergy. Allergen challenge leads to a rapid up-regulation of activation markers such as CD203c or CD63. Due to its restricted expression pattern, CD203c is discussed as a specific marker to monitor the allergen-induced activation of basophils, e.g., in flow cytometric basophil activation tests of the peripheral blood.
Additional information: Clone REA826 displays negligible binding to Fc receptors.

Alternative names

ENPP3, B10, NPP3, PD-IBETA, PDNP3, E-NPP3, PD-1b

Detailed product information

Technical specifications

CloneREA826
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD203c
Alternative names of antigenENPP3, B10, NPP3, PD-IBETA, PDNP3, E-NPP3, PD-1b
Molecular mass of antigen [kDa]100
Distribution of antigengranulocytes, basophils, liver, pancreas, small intestine
Entrez Gene ID5169
RRIDAB_2656161, AB_2656162, AB_2656163, AB_2656164, AB_2656165, AB_2656166, AB_2656167, AB_2656160

Resources for CD203c Antibody, anti-human, REAfinity™

Certificates

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References for CD203c Antibody, anti-human, REAfinity™

Publications

  1. Goding, J. W. (2000) Ecto-enzymes: physiology meets pathology. J. Leukoc. Biol. 67: 285-311
  2. Kahlert, H. et al. (2003) Measurement of basophil-activating capacity of grass pollen allergens, allergoids Clin. Exp. Allergy 33: 1266-1272
  3. Bühring, H. J. et al. (2004) The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int. Arch. Allergy Immunol. 133: 317-329
  4. Hauswirth, A. W. et al. (2002) Recombinant allergens promote expression of CD203c on basophils in sensitized individuals. J. Allergy Clin. Immunol. 110: 102-109

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