Clone:
REA958
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA

Specifications for CD181 (CXCR1) Antibody, anti-human, REAfinity™

Overview

Clone REA958 recognizes the human CD181 antigen, a multi-pass membrane protein also known as C-X-C chemokine receptor type 1 (CXCR1) or IL-8 receptor A (IL-8RA). CD181 is expressed as homodimer or heterodimer with CD182 (CXCR2) and found on granulocytes, natural killer (NK) cells, a subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. It is one of two high-affinity receptors for interleukin 8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumor growth. IL-8, released in response to inflammatory stimuli, binds to the extracellular part of CD181. The ligand-activated intracellular signaling pathways results in neutrophil migration to the site of inflammation.
Additional information: Clone REA958 displays negligible binding to Fc receptors.

Alternative names

CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA

Detailed product information

Technical specifications

CloneREA958
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD181 (CXCR1)
Alternative names of antigenCXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Molecular mass of antigen [kDa]40
Distribution of antigenendothelial cells, granulocytes, lymphocytes, mast cells, megakaryocytes, monocytes, NK cells, oligodendrocytes
Entrez Gene ID3577
RRIDAB_2727233, AB_2727277, AB_2727234, AB_2727278, AB_2727235, AB_2727282, AB_2727240, AB_2727281, AB_2727239, AB_2727283, AB_2727241, AB_2727279, AB_2727236, AB_2727237, AB_2727280, AB_2727238, AB_2801895, AB_2727276

Resources for CD181 (CXCR1) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD181 (CXCR1) Antibody, anti-human, REAfinity™

Publications

  1. Holmes, W. E. et al. (1991) Structure and functional expression of a human interleukin-8 receptor. Science 253(5025): 1278
  2. Cummings, C. J. et al. (1999) Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J. Immunol. 162(4): 2341-2346

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