Clone:
REA957
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Ly78, RP105

Specifications for CD180 (RP105) Antibody, anti-mouse, REAfinity™

Overview

Clone REA957 recognizes the mouse CD180 antigen, also known as RP105, a type I transmembrane protein structurally similar to toll-like receptors (TLRs) with the conserved features of TLRs, including a leucine-rich repeat extracellular domain and regions containing conserved cysteines. However, in contrast to TLRs, CD180 lacks a typical TIR domain, containing only 6–11 intracytoplasmic amino acids. Antibody mediated ligation of CD180 was shown to induce B cell proliferation and protection from subsequent radiation- or dexamethasone-induced apoptosis. Expression of CD180 is found on mature B cells, monocytes, macrophages, and dendritic cells. CD180 activity is dependent on physical association with a molecule called MD-1. In B cells, CD180, together with TLR4, has been shown to induce B cell proliferation in response to LPS. However, in primary myeloid cells and
in vivo
, CD180 acts as an inhibitor of TLR4 signaling.
Additional information: Clone REA957 displays negligible binding to Fc receptors.

Alternative names

Ly78, RP105

Detailed product information

Technical specifications

CloneREA957
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD180 (RP105)
Alternative names of antigenLy78, RP105
Distribution of antigendendritic cells, macrophages, monocytes, mature B cells
RRIDAB_2727228, AB_2727271, AB_2727229, AB_2727272, AB_2727230, AB_2727275, AB_2727232, AB_2727273, AB_2727231, AB_2727274, AB_2727269, AB_2727227, AB_2727270

Resources for CD180 (RP105) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD180 (RP105) Antibody, anti-mouse, REAfinity™

Publications

  1. Divanovic, S. et al. (2005) Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. J. Endotoxin Res. 11: 363-368
  2. Divanovic, S. et al. (2007) Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105. J. Leukoc. Biol. 82(2): 265-271

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