Clone:
REA1226
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr

Specifications for CD18 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1226 recognizes the murine CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Additional information: Clone REA1226 displays negligible binding to Fc receptors.

Alternative names

Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr

Detailed product information

Technical specifications

CloneREA1226
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD18
Alternative names of antigenIntegrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr
Molecular mass of antigen [kDa]42
Distribution of antigenleukocytes
Entrez Gene ID17000
RRIDAB_2819576, AB_2819577, AB_2819578, AB_2819579, AB_2819575

Resources for CD18 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD18 Antibody, anti-mouse, REAfinity™

Publications

  1. Wilson, R. W. et al. (1993) Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151: 1571-1578
  2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269
  3. Jakus, Z. et al. (2007) Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends Cell Biol. 17(10): 493-501

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