Clone:
REA1112
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ITGB2, LAD, LCAMB, LFA-1, Mac-1 α, MF17

Extended validation for CD18 Antibody, anti-human, REAfinity™

Specificity

View details
Overlay histogram showing flow cytometric analysis of CD18 knockout cells. Wild type (red) and knockout cells (blue) were stained with CD18-PE, clone (REA112). Flow cytometry was performed with the MACSQuant
®
Analyzer. Cell debris, dead cells and cell doublets were excluded from the analysis based on scatter signals and propidium iodide fluorescence.
Overlay histogram showing flow cytometric analysis of CD18 knockout cells. Wild type (red) and knockout cells (blue) were stained with CD18-PE, clone (REA112). Flow cytometry was performed with the MACSQuant
®
Analyzer. Cell debris, dead cells and cell doublets were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Specifications for CD18 Antibody, anti-human, REAfinity™

Overview

Clone REA1112 recognizes the human CD18 antigen, a type I transmembrane protein with an approximate molecular weight of 90–95 kDa. It non-covalently associates with α subunits CD11a (αL), CD11b (αM), CD11c (αX), and CD11d (αD) to form functional integrins which are expressed on leukocytes. CD18 associated integrins bind several ligands including cell surface and extracellular matrix proteins and are involved in cell-cell and cell-extracellular matrix interactions, immune regulation, and immune tolerance. Leucocytes of patients lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Additional information: Clone REA1112 displays negligible binding to Fc receptors.

Alternative names

ITGB2, LAD, LCAMB, LFA-1, Mac-1 α, MF17

Detailed product information

Technical specifications

CloneREA1112
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, other
Cross-reactivityporcine
AntigenCD18
Alternative names of antigenITGB2, LAD, LCAMB, LFA-1, Mac-1 α, MF17
Molecular mass of antigen [kDa]83
Distribution of antigenleukocytes
Entrez Gene ID3689
RRIDAB_2751669, AB_2751621, AB_2751670, AB_2751622

Resources for CD18 Antibody, anti-human, REAfinity™

Certificates

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References for CD18 Antibody, anti-human, REAfinity™

Publications

  1. Barber, D. F. et al. (2004) LFA-1 contributes an early signal for NK cell cytotoxicity. J. Immunol. 173(6): 3653-3659
  2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269

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