Clone:
REA490
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Sirp, Bit, Ptpns1, Shps1, Mfr, SIRPα

Specifications for CD172a (SIRPα) Antibody, anti-rat, REAfinity™

Overview

Clone REA490 recognizes the rat antigen CD172a, a 75–110 kDa glycosylated receptor-like protein, which is also known as SIRPα or SHPS-1. It binds to its ligand CD47, which inhibits cytokine production by mature dendritic cells (DCs) and avoids maturation of immature DCs. SHPS-1 plays a role in the negative regulation of receptor tyrosine kinase–coupled cellular responses induced by cell adhesion, growth factors, or insulin and mediates negative regulation of phagocytosis, mast cell, and DC activation. CD172a is expressed by neurons and myeloid cells, such as monocytes, macrophages, granulocytes, and DCs.
Additional information: Clone REA490 displays negligible binding to Fc receptors.

Alternative names

Sirp, Bit, Ptpns1, Shps1, Mfr, SIRPα

Detailed product information

Technical specifications

CloneREA490
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD172a (SIRPα)
Alternative names of antigenSirp, Bit, Ptpns1, Shps1, Mfr, SIRPα
Molecular mass of antigen [kDa]53
Distribution of antigendendritic cells, mast cells
Entrez Gene ID25528
RRIDAB_2655612, AB_2655613, AB_2655614, AB_2655615, AB_2655616, AB_2655617, AB_2655618, AB_2655611

Resources for CD172a (SIRPα) Antibody, anti-rat, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for CD172a (SIRPα) Antibody, anti-rat, REAfinity™

Publications

  1. Adams, S. et al. (1998) Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J. Immunol. 161: 1853-1859
  2. Takada, T. et al. (1998) Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. J. Biol. Chem. 273(15): 9234-9242
  3. Fujioka, Y. et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16(12): 6887-6899

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