Clone:
REA370
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
ALCAM, BEN, DM-GRASP, MuSC, SC1

Specifications for CD166 Antibody, anti-mouse, REAfinity™

Overview

Clone REA370 recognizes the mouse CD166 antigen, a Single-pass type I membrane protein also known as Activated leukocyte cell adhesion molecule (ALCAM). CD166 is a member of the immunoglobulin gene superfamily which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. It is also expressed at high levels in the brain and lung, at lower levels in the liver and the kidney, and on a number of cell lines. CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human hematopoietic stem cells (HSC) and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate.
Additional information: Clone REA370 displays negligible binding to Fc receptors.

Alternative names

ALCAM, BEN, DM-GRASP, MuSC, SC1

Detailed product information

Technical specifications

CloneREA370
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD166
Alternative names of antigenALCAM, BEN, DM-GRASP, MuSC, SC1
Molecular mass of antigen [kDa]62
Distribution of antigenthymic epithelial cells, brain, kidney, liver, lung
Entrez Gene ID11658
RRIDAB_2655520, AB_2655521, AB_2655522, AB_2655523, AB_2857719

Resources for CD166 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD166 Antibody, anti-mouse, REAfinity™

Publications

  1. Bowen, M. A. et al. (1997) Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding. Eur. J. Immunol. 27(6): 1469-1478
  2. Chitteti, B. R. et al. (2013) CD166 and regulation of hematopoiesis. Curr. Opin. Hematol. 20(4): 273-280
  3. Levin, T. G. et al. (2010) Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology 139(6): 2072-2082

Related products for
CD166 Antibody, anti-mouse, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?