Clone:
REA860
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
KIR2DS4

Extended validation for CD158i (KIR2DS4) Antibody, anti-human, REAfinity™

Sensitivity

Fixation data
To provide an indication on how an antibody performs after fixation of cells, in-house data on staining results before and after fixation with 3.7% formaldehyde using Miltenyi Biotec antibodies are provided. Different experimental settings may lead to different results.
No fixation
Post fixation
View details
Comparison of staining pattern on non-fixed and fixed cells using CD158i (KIR2DS4) (REA860). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.
View details
Comparison of staining pattern on non-fixed and fixed cells using CD158i (KIR2DS4) (REA860). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.
View details
Comparison of staining pattern on non-fixed and fixed cells using CD158i (KIR2DS4) (REA860). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.
View details
Comparison of staining pattern on non-fixed and fixed cells using CD158i (KIR2DS4) (REA860). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.
Comparison of staining pattern on non-fixed and fixed cells using CD158i (KIR2DS4) (REA860). The performance of the antibody after fixation was tested by comparing the staining pattern on fresh (no fixation) versus fixed (post fixation) cells.

Specifications for CD158i (KIR2DS4) Antibody, anti-human, REAfinity™

Overview

Clone REA860 recognizes the human CD158i antigen, also known as KIR2DS4, a member of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and some T cells. CD158i (KIR2DS4) provides an activation signal for NK lytic activity upon interaction with its ligand, HLA-Cw4, in an antigen-independent manner. KIRs are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains. The receptor family can be subdivided functionally according to the length of their cytoplasmic tail in inhibitory and activating KIRs.
Additional information: Clone REA860 displays negligible binding to Fc receptors.

Alternative names

KIR2DS4

Detailed product information

Technical specifications

CloneREA860
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD158i (KIR2DS4)
Alternative names of antigenKIR2DS4
Molecular mass of antigen [kDa]31
Distribution of antigenNK cells, T cells
Entrez Gene ID3809
RRIDAB_2655362, AB_2655363, AB_2655364, AB_2655365, AB_2655366, AB_2655367, AB_2655368, AB_2655369, AB_2655370, AB_2655371, AB_2655372, AB_2655373, AB_2655374, AB_2655375, AB_2655376, AB_2801684, AB_2801683, AB_2655377, AB_2655378, AB_2801907, AB_2655361

Resources for CD158i (KIR2DS4) Antibody, anti-human, REAfinity™

Documents and Protocols

App notes/customer reports

Cross-reactivity of KIR antibodies

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD158i (KIR2DS4) Antibody, anti-human, REAfinity™

Publications

  1. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
  2. Kratz, G. et al. (2004) MHC Class I-independent recognition of NK-activating receptor KIR2DS4. J. Immunol. 173: 1819-1825

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