Clone:
REA970
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
KIR3DL1, KIR3DL2

Extended validation for CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA970
REA1005n/a
DX9n/a
5.133++
Cells were incubated with an excess of purified unconjugated CD158e/k (KIR3DL1/DL2) (REA970) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

Overview

Clone REA970 recognizes the human CD158e (KIR3DL1) and CD158k (KIR3DL2) antigens, members of the killer immunoglobulin-like receptor (KIR) family which recognizes subsets of HLA alleles. The family of KIR contributes to the regulation of NK cell–mediated cytotoxicity. Expression is found mainly on CD56
dim
CD16
+
natural killer (NK) cells but also on a subset of CD8
+
T cells. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be subdivided in inhibitory KIRs and activating KIRs.
Additional information: Clone REA970 displays negligible binding to Fc receptors.

Alternative names

KIR3DL1, KIR3DL2

Detailed product information

Technical specifications

CloneREA970
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD158e/k (KIR3DL1/DL2)
Alternative names of antigenKIR3DL1, KIR3DL2
Distribution of antigenT cells, CD8+ T cells
Entrez Gene ID3811
RRIDAB_2727383, AB_2727447, AB_2727384, AB_2727448, AB_2727385, AB_2727450, AB_2727388, AB_2727449, AB_2727386, AB_2727387, AB_2727445, AB_2727382, AB_2727446

Resources for CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

Documents and Protocols

App notes/customer reports

Cross-reactivity of KIR antibodies

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

Publications

  1. Yawata, M. et al. (2002) Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family. Crit. Rev. Immunol. 22(5–6): 463-482
  2. Uhrberg, M. (2005) The KIR gene family: life in the fast lane of evolution. Eur. J. Immunol. 35(1): 10-15

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