Clone:
UC10-4B9
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
hamster IgG1
Applications:
FA, FC
Alternative names:
CTLA4, CTLA-4, Ly-56

Specifications for CD152 Antibody, anti-mouse

Overview

The monoclonal antibody UC10-4B9 reacts with CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a costimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152.

Alternative names

CTLA4, CTLA-4, Ly-56

Detailed product information

Technical specifications

CloneUC10-4B9
Clonalitymonoclonal
Isotypehamster IgG1
Hosthamster
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD152
Alternative names of antigenCTLA4, CTLA-4, Ly-56
Molecular mass of antigen [kDa]21
Distribution of antigenB cells, T cells
Entrez Gene ID12477
RRIDAB_2655252, AB_2655253, AB_2655254, AB_2655249

Resources for CD152 Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD152 Antibody, anti-mouse

Publications

  1. Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5): 405-413
  2. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
  3. June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15(7): 321-331

Seems like you are coming from USA!
Do you want to visit our website in your country?