Clone:
REA522
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ACE, ACE1, DCP, DCP1, ICH, MVCD3, Kininase II

Specifications for CD143 (ACE) Antibody, anti-human, REAfinity™

Overview

Clone REA522 recognizes the human CD143 antigen, a single-pass type I membrane protein, which is also known as angiotensin-converting enzyme (ACE). CD143, which exists in two isoforms (a 170 kDa somatic form and a 90 kDa germinal form), is part of the renin-angiotensin system (RAS), and increases blood pressure by causing blood vessels to constrict. It is secreted by cells in the endothelium of blood vessels in lungs and kidneys. The function of CD143 is to catalyse the conversion of angiotensin I to angiotensin II, which are also part of RAS. CD143 is highly regulated in different diseases, for example, sarcoidosis, acute hepatits, diabetis mellitus, multiple myeloma, and osteoarthritis. The somatic form is expressed by endothelial cells (especially those of arterioles and lung capillaries), epithelial cells (especially in proximal renal tubules and in the small intestine), by some neuronal cells, and variably on some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. Furthermore CD143 is expressed by hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues.
Additional information: Clone REA522 displays negligible binding to Fc receptors.

Alternative names

ACE, ACE1, DCP, DCP1, ICH, MVCD3, Kininase II

Detailed product information

Technical specifications

CloneREA522
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD143 (ACE)
Alternative names of antigenACE, ACE1, DCP, DCP1, ICH, MVCD3, Kininase II
Molecular mass of antigen [kDa]147(refers to canonical form)
Distribution of antigenepithelial cells, endothelial cells, T cells, macrophages, neuronal intestinal cells, hematopoietic stem and progenitor cells
Entrez Gene ID1636
RRIDAB_2655145, AB_2655146, AB_2655147, AB_2655148, AB_2655149, AB_2655144

Resources for CD143 (ACE) Antibody, anti-human, REAfinity™

Certificates

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References for CD143 (ACE) Antibody, anti-human, REAfinity™

Publications

  1. Jokubaitis, V. J. et al. (2008) Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Blood 111: 4055-4063
  2. Soubrier, F. et al. (1988) Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc. Natl. Acad. Sci. U.S.A. 85(24): 9386-9390
  3. Rohrbach, M. S. (1982) Pulmonary sarcoidosis and serum angiotensin-converting enzyme. Mayo Clin. Proc. 57(1): 64-66

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