Clone:
REA949
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Tissue Factor, Coagulation factor III, Thromboplastin, TF

Specifications for CD142 Antibody, anti-human, REAfinity™

Overview

Clone REA949 recognizes the human CD142 antigen, a 45 kDa type I transmembrane glycoprotein also known as tissue factor (TF). It functions as the high-affinity receptor for the coagulation factor VII and enables cells to initiate the blood coagulation cascades. It is reported, that the tissue factor exists in a membrane-bound and in a soluble form. It is expressed on activated endothelial cells and on monocytes, macrophages, and platelets, which are stimulated with inflammatory mediators such as LPS or tumor necrosis factor alpha (TNFα). CD142 is also present on some tumor cells such as lung, breast, pancreatic, and colon, as well as on non-immune-tissues.
Additional information: Clone REA949 displays negligible binding to Fc receptors

Alternative names

Tissue Factor, Coagulation factor III, Thromboplastin, TF

Detailed product information

Technical specifications

CloneREA949
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD142
Alternative names of antigenTissue Factor, Coagulation factor III, Thromboplastin, TF
Molecular mass of antigen [kDa]30
Distribution of antigenendothelial cells, macrophages, monocytes, platelets, tumor cells
Entrez Gene ID2152
RRIDAB_2801692, AB_2801699, AB_2801693, AB_2801700, AB_2801694, AB_2801701, AB_2801696, AB_2801695, AB_2801697, AB_2801691, AB_2801698

Resources for CD142 Antibody, anti-human, REAfinity™

Certificates

Please follow this
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References for CD142 Antibody, anti-human, REAfinity™

Publications

  1. Carson, S. D. et al. (1994) Fibroblast tissue factor: calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity. Blood 84: 526-534
  2. Golino, P. et al. (2002) The inhibitors of the tissue factor: factor VII pathway. Thromb. Res. 106(3): V257-V265
  3. Bogdanov, V. Y. et al. (2003) Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nat Med 9: 458-462
  4. Butenas, S. et al. (2008) Tissue factor activity and function in blood coagulation. Thromb. Res. 122: S42-S46

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