Clone:
TM-β1
Type of antibody:
Primary antibodies
Isotype:
rat IgG2bκ
Applications:
FC, MICS, IF, IHC
Alternative names:
IL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ

Specifications for CD122 (IL-2Rβ) Antibody, anti-mouse

Overview

The monoclonal antibody TM-ß1 recognizes the murine CD122 70–75 kDa cell surface glycoprotein, also known as interleukin-2 receptor beta chain (IL-2Rβ). CD122 is constitutively expressed on mouse NK cells and at a lower level on subsets of T cells, B cells, monocytes, and macrophages. CD122 can associate with the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25), resulting in intermediate or high affinity IL-2 receptor complexes. CD122 expression levels can be upregulated by activation. The TM-β1 antibody interferes with binding of IL-2 to the receptor and can be used to deplete CD122
+
cells.

Alternative names

IL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ

Detailed product information

Technical specifications

CloneTM-β1
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD122 (IL-2Rβ)
Alternative names of antigenIL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ
Molecular mass of antigen [kDa]58
Distribution of antigenB cells, T cells, monocytes, macrophages, NK cells
Entrez Gene ID16185
RRIDAB_2654767, AB_2654768, AB_2654769, AB_2654770, AB_2654771, AB_2654772, AB_2654773, AB_2654766

Resources for CD122 (IL-2Rβ) Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD122 (IL-2Rβ) Antibody, anti-mouse

Publications

  1. Tanaka, T. et al. (1991) A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL- 4 J. Immunol. 147: 2222-2228
  2. Tang, Y. et al. (2011) Emergence of NK cell progenitors and functionally competent NK cell lineage subsets in the early mouse embryo. Blood 120: 63-75
  3. Taniguchi, T. et al. (1993) The IL-2/IL-2 receptor system: a current overview. Cell 73(1): 5-8
  4. Malek, T. R. et al. (1995) Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. J. Interferon Cytokine Res. 15(5): 447-454
  5. Nishikawa, Y. et al. (2010)
    Roles of CD122
    +
    cells in resistance against
    Neospora caninum
    infection in a murine model.
    J. Vet. Med. Sci. 72(10): 1275-1282

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