Clone:
REA1082
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CSF-3R, G-CSFR

Specifications for CD114 Antibody, anti-human, REAfinity™

Overview

Clone REA1082 recognizes the receptor for granulocyte colony stimulating factor (G-CSFR, CSF3) a 130–150 kDa type I transmembrane glycoprotein of the class 1 cytokine receptor gene family also known as CD114. Ligand binding leads to homodimerization and subsequent signal transduction involving the JAK-STAT pathway. CD114 is expressed by neutrophils at all stages of differentiation but also found on monocytes, endothelial cells, mature platelets, trophoblasts, and placenta.
Additional information: Clone REA1082 displays negligible binding to Fc receptors.

Alternative names

CSF-3R, G-CSFR

Detailed product information

Technical specifications

CloneREA1082
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD114
Alternative names of antigenCSF-3R, G-CSFR
Molecular mass of antigen [kDa]90
Distribution of antigenendothelial cells, granulocytes, monocytes, platelets, neutrophils
Entrez Gene ID1441
RRIDAB_2733754, AB_2733755, AB_2733332, AB_2733333, AB_2733496, AB_2733497

Resources for CD114 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD114 Antibody, anti-human, REAfinity™

Publications

  1. Ward, A. C. (2007) The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease. Front Biosci. 12: 608-618
  2. Liongue, C. et al. (2009) Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int. J. Biochem. Cell Biol. 12(41): 2372-2375
  3. Piper, M. G. et al. (2010) Neutrophil elastase downmodulates native GCSFR expression and granulocyte-macrophage colony formation. J. Inflamm. 7(1): 5
  4. Gibbs, K. D. et al. (2011) Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood 117: 4226-4233

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