Clone:
REAL1098
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC, MICS, IHC, IF
Alternative names:
VCAM1, INCAM-100, Vascular cell adhesion protein 1 (V-CAM 1, VCAM-1)

Specifications for CD106 (VCAM-1) Antibody, anti-mouse,
REAlease
®

Overview

Clone REAL1098 is an antibody fragment derived from the full CD106 (VCAM-1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REA1098 recognizes the mouse CD106 antigen, a 110 kDa single chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow, stromal cells and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

VCAM1, INCAM-100, Vascular cell adhesion protein 1 (V-CAM 1, VCAM-1)

Detailed product information

Technical specifications

CloneREAL1098
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD106 (VCAM-1)
Alternative names of antigenVCAM1, INCAM-100, Vascular cell adhesion protein 1 (V-CAM 1, VCAM-1)
Distribution of antigenendothelial cells, stromal cells, bone marrow

Resources for CD106 (VCAM-1) Antibody, anti-mouse,
REAlease
®

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD106 (VCAM-1) Antibody, anti-mouse,
REAlease
®

Publications

  1. Kumar, A. G. et al. (1994) Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form J. Immunol. 153(9): 4088-4098
  2. Ou, R. et al. (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J. Virol. 82(6): 2952-2965
  3. Kokovay, E. et al. (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression Cell Stem Cell 11(2): 220-230

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