Clone:
REA346
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
C-C motif chemokine 5, SCYA5, SIS-delta, SISd, TCP228, EoCP, T-cell-specific protein RANTES, RANTES

Specifications for CCL5 (RANTES) Antibody, anti-human, REAfinity™

Overview

Clone REA346 recognizes the human C-C motif chemokine 5 (CCL5) antigen, a 8 kDa protein also known as RANTES (regulated on activation, normal T cell expressed and secreted). CCL5 belongs to the C-C chemokine family and is a target gene of NF-κB activity. It is expressed by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells. NF-κB activation by different stimuli such as CD40L or interleukin 15 (IL-15) induces CCL5 production. CCL5 plays an active role in recruiting a variety of leukocytes into inflammatory sites including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and interferon γ (IFN-γ), CCL5 also induces the activation and proliferation of particular natural killer cells to generate C-C chemokine-activated killer cells. CCL5 produced by CD8
+
T cells and other immune cells has been shown to inhibit HIV entry into target cells. CCL5 activity is mediated through its binding to CCR1, CCR3, and mainly CCR5. CCR4 and CD44 are auxiliary receptors for CCL5.
Additional information: Clone REA346 displays negligible binding to Fc receptors.

Alternative names

C-C motif chemokine 5, SCYA5, SIS-delta, SISd, TCP228, EoCP, T-cell-specific protein RANTES, RANTES

Detailed product information

Technical specifications

CloneREA346
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenCCL5 (RANTES)
Alternative names of antigenC-C motif chemokine 5, SCYA5, SIS-delta, SISd, TCP228, EoCP, T-cell-specific protein RANTES, RANTES
Molecular mass of antigen [kDa]8(average of subunits)
Distribution of antigenT cells, macrophages, platelets, epithelial cells, fibroblasts, lymphocytes
Entrez Gene ID6352
RRIDAB_2651391, AB_2651392, AB_2651393, AB_2651394

Resources for CCL5 (RANTES) Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CCL5 (RANTES) Antibody, anti-human, REAfinity™

Publications

  1. Schall, T. J. et al. (1988) A human T cell-specific molecule is a member of a new gene family J. Immunol. 141(3): 1018-1025
  2. Capoulade-Métay, C. et al. (2006) A natural CCL5/RANTES variant antagonist for CCR1 and CCR3. Immunogenetics 58(7): 533-541
  3. Long, H. et al. (2012)
    Autocrine CCL5 signaling promotes invasion and migration of CD133
    +
    ovarian cancer stem-like cells via NF-κB-mediated MMP-9 up regulation.
    Stem Cells 30(10): 2309-2319

Related products for
CCL5 (RANTES) Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?