Clone:
REA487
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
AMAC-1, CKb7, MIP-4, PARC, SCYA18, DC-CK1

Specifications for CCL18 (MIP-4) Antibody, anti-human, REAfinity™

Overview

Clone REA487 recognizes the C-C motif chemokine 18 (CCL18) antigen, a secreted protein also known as macrophage inflammatory protein 4 (MIP-4) or dendritic cell chemokine 1 (DC-CK1). CCL18 is a cytokine belonging to the members of the CC subfamily of chemokines. Chemokines are chemotactic cytokines that guide the directed migration of leukocytes in the steady-state and in inflammation through a subfamily of seven-transmembrane spanning G protein–coupled receptors. CCL18 is secreted primarily by cells of the myeloid lineage and has been identified in alveolar macrophages, tolerogenic dendritic cells, alternatively activated macrophages (AAMs), and keratinocytes. In macrophages, CCL18 is induced by the Tʜ2 cytokines IL-4 and IL-13, which program macrophages to differentiate into AAMs. CCL18 is highly expressed in many human chronic inflammatory diseases, which include pulmonary fibrosis and certain cancers, and a wide range of allergic diseases. In some diseases, the level of circulating CCL18 has been demonstrated to be a biomarker for disease activity and outcome.
Additional information: Clone REA487 displays negligible binding to Fc receptors.

Alternative names

AMAC-1, CKb7, MIP-4, PARC, SCYA18, DC-CK1

Detailed product information

Technical specifications

CloneREA487
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCCL18 (MIP-4)
Alternative names of antigenAMAC-1, CKb7, MIP-4, PARC, SCYA18, DC-CK1
Molecular mass of antigen [kDa]8(refers to CCL18(1-68))
Distribution of antigendendritic cells, macrophages, keratinocytes, monocytes
Entrez Gene ID6362
RRIDAB_2651355, AB_2651356

Resources for CCL18 (MIP-4) Antibody, anti-human, REAfinity™

Certificates

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References for CCL18 (MIP-4) Antibody, anti-human, REAfinity™

Publications

  1. Hieshima, K. et al. (1997) A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes. J. Immunol. 159(3): 1140-1149
  2. Islam, S. A. et al. (2013) Identification of human CCR8 as a CCL18 receptor. J. Exp. Med. 210(10): 1889-1898

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