Clone:
REA752
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
p150, T-cad, T-cadherin

Specifications for Cadherin-13 Antibody, anti-human, REAfinity™

Overview

Clone REA752 recognizes the human cadherin-13 antigen, also known as T-Cadherin or H-Cadherin (heart cadherin). Cadherin-13 is a transmembrane glycoprotein that mediates calcium-dependent intercellular adhesion.
It is suggested that cadherin-13 may function as a negative regulator of neural cell growth. Cadherin-13 is expressed human adult cerebral cortex, medulla, thalamus, and midbrain. In developing brain, a lower expression is found than in adult brain. Furthermore, cadherin-13 is expressed in the basal layer of the epidermis, lung, liver, kidney, and blood vessels. It is reported, that cadherin-13 could be used as a marker for breast cancer development.
Additional information: Clone REA752 displays negligible binding to Fc receptors.

Alternative names

p150, T-cad, T-cadherin

Detailed product information

Technical specifications

CloneREA752
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse
AntigenCadherin-13
Alternative names of antigenp150, T-cad, T-cadherin
Molecular mass of antigen [kDa]61
Distribution of antigenother, brain
Entrez Gene ID1012
RRIDAB_2651309, AB_2651310, AB_2651311, AB_2651312, AB_2651313, AB_2651314, AB_2651315, AB_2651308

Resources for Cadherin-13 Antibody, anti-human, REAfinity™

Certificates

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References for Cadherin-13 Antibody, anti-human, REAfinity™

Publications

  1. Lee, S. W. (1996) H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Nat Med 2(7): 776-782
  2. Takeuchi, T. et al. (2000) Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells. J. Neurochem. 74(4): 1489-1497
  3. Philippova, M. et al. (2009) A guide and guard: the many faces of T-cadherin. Cell. Signal. 21(7): 1035-1044

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