Scientists describe how UltraMicroscope 3D light sheet imaging helped them advance their research
Conducting a research study and ultimately publishing the results can be a rocky road: from designing the project and overcoming emerging challenges to enjoying what you’ve accomplished. During the ongoing pandemic we had the opportunity to speak with authors of recent papers covering a wide range of research fields – from cardiovascular research and immuno-oncology through to virology. In these short videos, recorded during an online call, the authors share their experiences working on their projects and describe how they reached their goals. They all used 3D light sheet microscopy and UltraMicroscope technology to support their hypotheses and advance their research.
The evolution of 3D vision – understanding the cellular basis
Read more about this study and have a look at the data:
Vigouroux, R. et al. (2021) Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods. Science 372: 150–156. DOI: 10.1126/science.abe7790.
Pancreatic cancer models – evidence for direct interaction between myeloid-derived suppressor cells and regulatory T cells
Read more about this study and have a look at the data:
Siret, C. et al. (2020) Deciphering the crosstalk between myeloid-derived suppressor cells and regulatory T cells in pancreatic ductal adenocarcinoma. Front. Immunol. 10: 3070. DOI: 10.3389/fimmu.2019.03070.
NK cells protect the brain – how the UltraMicroscope advances stroke research
Read more about this study and have a look at the data:
Wang, S. et al. (2021) Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke. bioRxiv: preprint. DOI: 10.1101/2021.02.18.431426.
The UltraMicroscope sheds light on the mechanism of viral pathogenesis
Read more about this study and have a look at the data:
Zaeck, L.M. et al. (2021) Light sheet microscopy-assisted 3D analysis of SARS-CoV-2 infection in the respiratory tract of the ferret model. Viruses 13: 529. DOI: 10.3390/v13030529.
Insights into heart damage and response processes caused by infarction
Read more about this study and have a look at the data:
Merz, S.F., Korste, S., Bornemann, L. et al. (2019) Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response. Nat. Commun. 10: 2312. DOI: 10.1038/s41467-019-10338-2.
Discovering non-conventional macrophages in the brain
Read more about this study and have a look at the data:
Siret, C. et al. (2021) Identification and characterization of a non-conventional CD45 negative perivascular macrophage population within the mouse brain. Research Square: preprint. DOI: 10.21203/rs.3.rs-479980.
